LMPD Database

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LMP008007

UniProt Annotations

Entry Information
Gene NameProtein DHS-16
Protein EntryDHS16_CAEEL
UniProt IDO16881
SpeciesC. elegans
Comments
Comment typeDescription
Function3 beta-hydroxysteroid dehydrogenase that converts 3 beta-hydroxysteroids to 3-ketosteroids, an essential step in the production of delta(7)-dafachronic acid from cholesterol. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. Required for longevity in the absence of the germline. {ECO:0000269|PubMed:22505847}.
PathwaySteroid hormone biosynthesis; dafachronic acid biosynthesis. {ECO:0000269|PubMed:22505847}.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityStrongly expressed in the hypodermis and posterior pharyngeal bulb and in a number of unidentified neurons of the head and tail. {ECO:0000269|PubMed:22505847}.