LMPD Database

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LMP007919

UniProt Annotations

Entry Information
Gene NameProtein DAD-1
Protein EntryDAD1_CAEEL
UniProt IDP52872
SpeciesC. elegans
Comments
Comment typeDescription
Catalytic ActivityDolichyl diphosphooligosaccharide + [protein]- L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.
FunctionEssential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains (By similarity). Possesses cell death- inhibiting activity. Suppresses some programmed cell death in C.elegans. {ECO:0000250}.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the DAD/OST2 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
SubunitComponent of the oligosaccharyltransferase (OST) complex. {ECO:0000250}.