LMPD Database

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LMP007827

UniProt Annotations

Entry Information
Gene NameProtein FAT-4
Protein EntryFAT4_CAEEL
UniProt IDG5EG11
SpeciesC. elegans
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=a; IsoId=G5EG11-1; Sequence=Displayed; Name=b; IsoId=G5EG11-2; Sequence=VSP_047789; Name=c; IsoId=G5EG11-3; Sequence=VSP_047788;
FunctionCatalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) to generate arachidonic acid (20:4n-6). Also acts on a number of other substrates, including fatty acids that do not contain a double bond at the 8 position. {ECO:0000269|PubMed:11972048, ECO:0000269|PubMed:9845325, ECO:0000269|PubMed:9917342}.
PathwayLipid metabolism; polyunsaturated fatty acid biosynthesis. {ECO:0000269|PubMed:11972048, ECO:0000269|PubMed:9845325, ECO:0000269|PubMed:9917342}.
SimilarityBelongs to the fatty acid desaturase family. {ECO:0000305}.
SimilarityContains 1 cytochrome b5 heme-binding domain. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.