LMPD Database

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LMP007626

UniProt Annotations

Entry Information
Gene Nameglycerophosphodiester phosphodiesterase, cytosolic
Protein EntryUGPQ_ECOLI
UniProt IDP10908
SpeciesE. coli
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=0.22 mM for glycerophosphoethanolamine {ECO:0000269|PubMed:18083802}; KM=0.66 mM for glycerophosphoserine {ECO:0000269|PubMed:18083802}; KM=0.62 mM for glycerophosphoglycerol {ECO:0000269|PubMed:18083802}; KM=0.39 mM for glycerophosphoinositol {ECO:0000269|PubMed:18083802}; KM=2.0 mM for glycerophosphocholine {ECO:0000269|PubMed:18083802}; pH dependence: Optimum pH is 7.5. {ECO:0000269|PubMed:18083802};
Catalytic ActivityA glycerophosphodiester + H(2)O = an alcohol + sn-glycerol 3-phosphate. {ECO:0000269|PubMed:18083802}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:18083802}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000269|PubMed:18083802}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:18083802};
FunctionGlycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols.
InductionUp-regulated by low levels of phosphate in the medium. {ECO:0000269|PubMed:18083802}.
MiscellaneousThere are 2 isozymes of glycerophosphoryl diester phosphodiesterase in E.coli: a periplasmic isozyme (GlpQ) and a cytosolic isozyme (UgpQ).
SimilarityBelongs to the glycerophosphoryl diester phosphodiesterase family. {ECO:0000305}.
SimilarityContains 1 GP-PDE domain. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:18083802}.