LMPD Database

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LMP007595

UniProt Annotations

Entry Information
Gene Nameundecaprenyl phosphate-alpha-L-ara4FN deformylase
Protein EntryARND_ECOLI
UniProt IDP76472
SpeciesE. coli
Comments
Comment typeDescription
Catalytic Activity4-deoxy-4-formamido-beta-L-arabinose di- trans,poly-cis-undecaprenyl phosphate + H(2)O = 4-amino-4-deoxy- alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate. {ECO:0000255|HAMAP-Rule:MF_01870, ECO:0000269|PubMed:15695810}.
FunctionCatalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (Probable). {ECO:0000305|PubMed:15695810}.
InductionInduced by BasR. {ECO:0000250}.
InteractionP0A6F5:groL; NbExp=1; IntAct=EBI-1128209, EBI-543750;
PathwayBacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01870, ECO:0000269|PubMed:17928292}.
PathwayGlycolipid biosynthesis; 4-amino-4-deoxy-alpha-L- arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy- alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4- formamido-beta-L-arabinose and undecaprenyl phosphate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_01870, ECO:0000269|PubMed:17928292}.
SimilarityBelongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. {ECO:0000255|HAMAP-Rule:MF_01870}.
SimilarityContains 1 NodB homology domain. {ECO:0000255|HAMAP- Rule:MF_01870}.