LMPD Database

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LMP007545

UniProt Annotations

Entry Information
Gene Name1,4-dihydroxy-2-naphthoate octaprenyltransferase
Protein EntryMENA_ECOLI
UniProt IDP32166
SpeciesE. coli
Comments
Comment typeDescription
Catalytic ActivityAn all-trans-polyprenyl diphosphate + 1,4- dihydroxy-2-naphthoate = a demethylmenaquinol + diphosphate + CO(2).
FunctionConversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages: the removal of the carboxyl group of DHNA as CO(2), the attachment of the isoprenoid side chain, and a quinol-to-quinone oxidation, which is thought to be spontaneous.
PathwayQuinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.
SimilarityBelongs to the MenA family. {ECO:0000305}.
Subcellular LocationCell inner membrane; Multi-pass membrane protein.