LMPD Database

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LMP007518

UniProt Annotations

Entry Information
Gene Namestearoyl-CoA 9-desaturase
Protein EntryACO1_YEAST
UniProt IDP21147
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityStearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O.
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875;
DomainThe histidine box domains may contain the active site and/or be involved in metal ion binding.
FunctionUtilizes O(2) and electrons from the reduced cytochrome b(5) domain to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates
FunctionUtilizes O(2) and electrons from the reduced cytochrome b(5) domain to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates. {ECO:0000305}.
InteractionSelf; NbExp=1; IntAct=EBI-2098, EBI-2098; P25376:AGP1; NbExp=1; IntAct=EBI-2098, EBI-2357; P36076:CAB3; NbExp=1; IntAct=EBI-2098, EBI-26778; P08456:CHO1; NbExp=1; IntAct=EBI-2098, EBI-14055; P47133:EMC2; NbExp=1; IntAct=EBI-2098, EBI-25568; P10614:ERG11; NbExp=1; IntAct=EBI-2098, EBI-5127; P54781:ERG5; NbExp=1; IntAct=EBI-2098, EBI-6563; P54837:ERV25; NbExp=1; IntAct=EBI-2098, EBI-6642; P19145:GAP1; NbExp=1; IntAct=EBI-2098, EBI-7314; Q04697:GSF2; NbExp=1; IntAct=EBI-2098, EBI-27807; P40540:KRE27; NbExp=1; IntAct=EBI-2098, EBI-24977; P36027:MID2; NbExp=1; IntAct=EBI-2098, EBI-10901; P41543:OST1; NbExp=1; IntAct=EBI-2098, EBI-12651; Q12746:PGA3; NbExp=1; IntAct=EBI-2098, EBI-27973; P25297:PHO84; NbExp=1; IntAct=EBI-2098, EBI-13320; P38264:PHO88; NbExp=1; IntAct=EBI-2098, EBI-13350; P40975:PMP2; NbExp=1; IntAct=EBI-2098, EBI-2043041; P26570:PPZ1; NbExp=1; IntAct=EBI-2098, EBI-13807; Q04947:RTN1; NbExp=1; IntAct=EBI-2098, EBI-38020; P32368:SAC1; NbExp=1; IntAct=EBI-2098, EBI-16210; P14906:SEC63; NbExp=1; IntAct=EBI-2098, EBI-16636; P39986:SPF1; NbExp=1; IntAct=EBI-2098, EBI-3128; Q12256:TPO4; NbExp=1; IntAct=EBI-2098, EBI-37213; P25037:UBP1; NbExp=1; IntAct=EBI-2098, EBI-19819; P40107:VRG4; NbExp=1; IntAct=EBI-2098, EBI-7764; Q03362:YDR476C; NbExp=1; IntAct=EBI-2098, EBI-2057915; P35723:YET1; NbExp=1; IntAct=EBI-2098, EBI-26730;
SimilarityBelongs to the fatty acid desaturase family
SimilarityBelongs to the fatty acid desaturase family. {ECO:0000305}.
SimilarityContains 1 cytochrome b5 heme-binding domain
SimilarityContains 1 cytochrome b5 heme-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00279}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein .
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.