LMPD Database

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LMP007486

UniProt Annotations

Entry Information
Gene Nameketol-acid reductoisomerase
Protein EntryILV5_YEAST
UniProt IDP06168
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.
Catalytic Activity(R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 2 magnesium ions per subunit. {ECO:0000250};
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Note=Binds 2 magnesium ions per subunit. ;
MiscellaneousPresent with 883000 molecules/cell in log phase SD medium
MiscellaneousPresent with 883000 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayAmino-acid biosynthesis; L-isoleucine biosynthesis; L- isoleucine from 2-oxobutanoate: step 2/4.
PathwayAmino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.
SimilarityBelongs to the ketol-acid reductoisomerase family
SimilarityBelongs to the ketol-acid reductoisomerase family. {ECO:0000305}.
Subcellular LocationMitochondrion.