LMPD Database

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LMP007484

UniProt Annotations

Entry Information
Gene Nametype 2C protein phosphatase PTC6
Protein EntryPDP2_YEAST
UniProt IDP25646
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity[Pyruvate dehydrogenase (acetyl-transferring)] phosphate + H(2)O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate.
Disruption PhenotypeConfers rapamycin-sensitivity. {ECO:0000269|PubMed:17002782}.
FunctionCatalyzes the dephosphorylation and concomitant reactivation of the E1 alpha subunit (PDA1) of the pyruvate dehydrogenase complex. Required for efficient mitophagy in stationary phase cells. {ECO:0000269|PubMed:17002782, ECO:0000269|PubMed:17166847, ECO:0000269|PubMed:18180296}.
MiscellaneousPresent with 432 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityContains 1 PP2C-like domain. {ECO:0000305}.
Subcellular LocationMitochondrion intermembrane space. Mitochondrion matrix.
SubunitInteracts with PRO2. {ECO:0000269|Ref.4}.