LMPD Database

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LMP007373

UniProt Annotations

Entry Information
Gene Nameketoreductase
Protein EntryMKAR_YEAST
UniProt IDP38286
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityA very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH
Catalytic ActivityA very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH. {ECO:0000255|HAMAP-Rule:MF_03107, ECO:0000269|PubMed:12087109}.
FunctionComponent of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. {ECO:0000255|HAMAP-Rule:MF_03107, ECO:0000269|PubMed:11792704, ECO:0000269|PubMed:12087109, ECO:0000269|PubMed:12684876}.
MiscellaneousPresent with 41900 molecules/cell in log phase SD medium
MiscellaneousPresent with 41900 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000255|HAMAP-Rule:MF_03107}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03107}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03107}.
Subcellular LocationEndoplasmic reticulum membrane ; Single-pass membrane protein .
SubunitInteracts with the fatty acid elongation system components ELO3 and TSC13. {ECO:0000255|HAMAP-Rule:MF_03107, ECO:0000269|PubMed:12087109}.