LMPD Database

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LMP007346

UniProt Annotations

Entry Information
Gene NamePho81p
Protein EntryPHO81_YEAST
UniProt IDP17442
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionInhibits the kinase activity of the cyclin-CDKs PHO80- PHO85 and PCL7-PHO85 under low-phosphate conditions. {ECO:0000269|PubMed:11069666, ECO:0000269|PubMed:7939631, ECO:0000269|PubMed:7957107}.
InteractionP17157:PHO85; NbExp=5; IntAct=EBI-13314, EBI-13327;
MiscellaneousPresent with 2930 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PtmPhosphorylated by the cyclin-CDK PHO80-PHO85. Phosphorylation mediates the formation of a stable interaction with the cyclin-CDK and is required for function as an active inhibitor of the complex under phosphate starvation conditions. {ECO:0000269|PubMed:15057567, ECO:0000269|PubMed:15127225, ECO:0000269|PubMed:18407956}.
SimilarityContains 1 GP-PDE domain. {ECO:0000305}.
SimilarityContains 1 SPX domain. {ECO:0000255|PROSITE- ProRule:PRU00714}.
SimilarityContains 6 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular LocationCytoplasm. Nucleus. Note=Localizes predominantly to the nucleus in both high- and low-phosphate conditions.
SubunitAssociates specifically with the PHO80-PHO85 and PCL7- PHO85 cyclin-CDK complexes, and much of this interaction is mediated through the PHO80 and PCL7 cyclin subunits. Interacts with the transcription factor PHO4. {ECO:0000269|PubMed:11069666, ECO:0000269|PubMed:7939631, ECO:0000269|PubMed:7957107}.