LMPD Database

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LMP007263

UniProt Annotations

Entry Information
Gene NameGDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase
Protein EntryALG2_YEAST
UniProt IDP43636
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityGDP-D-mannose + D-Man-alpha-(1->3)-D-Man-beta- (1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D- Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc- beta-(1->4)-D-GlcNAc-diphosphodolichol
Catalytic ActivityGDP-D-mannose + D-Man-alpha-(1->3)-D-Man-beta- (1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D- Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc- beta-(1->4)-D-GlcNAc-diphosphodolichol. {ECO:0000269|PubMed:16878994}.
Catalytic ActivityGDP-D-mannose + D-Man-beta-(1->4)-D-GlcNAc- beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)- D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-GlcNAc-diphosphodolichol
Catalytic ActivityGDP-D-mannose + D-Man-beta-(1->4)-D-GlcNAc- beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)- D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-GlcNAc-diphosphodolichol. {ECO:0000269|PubMed:16878994}.
FunctionMannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate
FunctionMannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate. {ECO:0000269|PubMed:16878994}.
InteractionP16661:ALG1; NbExp=2; IntAct=EBI-2459, EBI-2206309;
MiscellaneousPresent with 1840 molecules/cell in log phase SD medium
MiscellaneousPresent with 1840 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily
SimilarityBelongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:15044395}; Multi-pass membrane protein {ECO:0000269|PubMed:15044395}.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .
SubunitInteracts with ALG1
SubunitInteracts with ALG1. {ECO:0000269|PubMed:15044395}.