LMPD Database

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LMP007247

UniProt Annotations

Entry Information
Gene Nametype 2C protein phosphatase PTC1
Protein EntryPP2C1_YEAST
UniProt IDP35182
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium or manganese ions per subunit. Manganese is about 20 times more efficient than magnesium.;
FunctionIt has a serine and a weak tyrosine phosphatase activity with ratios of serine to tyrosine phosphatase activity as high as 200:1. It is essential for growth or germination at 37 degrees Celsius. May have a role in the heat shock response. Involved in tRNA splicing and cell separation.
InteractionQ12163:NBP2; NbExp=4; IntAct=EBI-12784, EBI-34713;
MiscellaneousPresent with 1520 molecules/cell in log phase SD medium
MiscellaneousPresent with 1520 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the PP2C family
SimilarityBelongs to the PP2C family. {ECO:0000305}.
SubunitInteracts with NBP2 and PBS2
SubunitInteracts with NBP2 and PBS2. {ECO:0000269|PubMed:14685261}.