LMPD Database

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LMP007232

UniProt Annotations

Entry Information
Gene Namephosphoprotein phosphatase 2A catalytic subunit PPH22
Protein EntryPP2A2_YEAST
UniProt IDP23595
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 manganese ions per subunit. {ECO:0000250};
FunctionExact function not known, phosphatase 2A performs an essential cellular function.
InteractionP38074:HMT1; NbExp=3; IntAct=EBI-12752, EBI-8394; Q04372:TAP42; NbExp=4; IntAct=EBI-12752, EBI-18926; Q12199:TIP41; NbExp=3; IntAct=EBI-12752, EBI-38123;
MiscellaneousPresent with 4110 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PtmReversibly methyl esterified on Leu-377 by leucine carboxyl methyltransferase 1 (PPM1) and protein phosphatase methylesterase 1 (PPE1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization. {ECO:0000269|PubMed:11060018, ECO:0000269|PubMed:11697862}.
SimilarityBelongs to the PPP phosphatase family. PP-2A subfamily. {ECO:0000305}.
SubunitInactivated in a complex with phosphatase methylesterase PPE1 (PP2Ai). Interacts with phosphatase 2A activator RRD2, which can reactivate PP2Ai by dissociating the catalytic subunit from the complex. Interacts with TAP42. {ECO:0000269|PubMed:14551259, ECO:0000269|PubMed:15447631}.