LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP007221

UniProt Annotations

Entry Information
Gene NameGwt1p
Protein EntryGWT1_YEAST
UniProt IDP47026
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionProbable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI- anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins
FunctionProbable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI- anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins. {ECO:0000269|PubMed:12714589, ECO:0000269|PubMed:12753194}.
InteractionQ12127:CCW12; NbExp=1; IntAct=EBI-25989, EBI-5303; Q05359:ERP1; NbExp=1; IntAct=EBI-25989, EBI-6581; P54837:ERV25; NbExp=1; IntAct=EBI-25989, EBI-6642; P38694:MSC7; NbExp=1; IntAct=EBI-25989, EBI-24511;
MiscellaneousTarget of the antifungal compound 1-[4- butylbenzyl]isoquinoline that inhibits cell wall localization of GPI-anchored mannoproteins.
PathwayGlycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Sequence CautionSequence=CAA58476.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA89384.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence CautionSequence=CAA58476.1; Type=Erroneous initiation; Evidence= ; Sequence=CAA89384.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the PIGW family
SimilarityBelongs to the PIGW family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:12714589, ECO:0000269|PubMed:14562095}; Multi- pass membrane protein {ECO:0000269|PubMed:12714589, ECO:0000269|PubMed:14562095}.
Subcellular LocationEndoplasmic reticulum membrane ; Multi- pass membrane protein {ECO:0000269|PubMed:12714589, ECO:0000269|PubMed:14562095}.