LMPD Database

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LMP007215

UniProt Annotations

Entry Information
Gene Nameputative serine/threonine-protein kinase PPG1
Protein EntryPP2A4_YEAST
UniProt IDP32838
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 manganese ions per subunit. {ECO:0000250};
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Note=Binds 2 manganese ions per subunit. ;
FunctionInvolved in glycogen accumulation.
MiscellaneousPresent with 1960 molecules/cell in log phase SD medium
MiscellaneousPresent with 1960 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PtmReversibly methyl esterified on Leu-368 by leucine carboxyl methyltransferase 1 (PPM1) and protein phosphatase methylesterase 1 (PPE1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization.
SimilarityBelongs to the PPP phosphatase family. PP-2A subfamily
SimilarityBelongs to the PPP phosphatase family. PP-2A subfamily. {ECO:0000305}.
SubunitInactivated in a complex with phosphatase methylesterase PPE1 (PP2Ai). Interacts with phosphatase 2A activator RRD1, which can reactivate PP2Ai by dissociating the catalytic subunit from the complex. Interacts with TAP42. {ECO:0000269|PubMed:14551259, ECO:0000269|PubMed:15447631}.