LMPD Database

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LMP007181

UniProt Annotations

Entry Information
Gene NameCDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Protein EntryPGPS1_YEAST
UniProt IDP25578
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityCDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate
Catalytic ActivityCDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate. {ECO:0000269|PubMed:9545322}.
FunctionEssential for the viability of mitochondrial petite mutant. Catalyzes the committed step to the synthesis of the acidic phospholipids
FunctionEssential for the viability of mitochondrial petite mutant. Catalyzes the committed step to the synthesis of the acidic phospholipids. {ECO:0000269|PubMed:9545322}.
InductionRepressed by inositol and choline
InductionRepressed by inositol and choline. {ECO:0000269|PubMed:9799363}.
PathwayPhospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Sequence CautionSequence=CAA88175.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA88175.1; Type=Frameshift; Positions=503; Evidence={ECO:0000305};
Sequence CautionSequence=CAA88175.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=CAA88175.1; Type=Frameshift; Positions=503; Evidence= ;
SimilarityBelongs to the CDP-alcohol phosphatidyltransferase class-II family
SimilarityBelongs to the CDP-alcohol phosphatidyltransferase class-II family. {ECO:0000305}.
SimilarityContains 2 PLD phosphodiesterase domains
SimilarityContains 2 PLD phosphodiesterase domains. {ECO:0000255|PROSITE-ProRule:PRU00153}.
Subcellular LocationMitochondrion {ECO:0000269|PubMed:9545322, ECO:0000269|PubMed:9799363}.