LMPD Database

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LMP007161

UniProt Annotations

Entry Information
Gene NameCsr1p
Protein EntryCSR1_YEAST
UniProt IDQ06705
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionNon-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Activates SPO14/PLD1 (phospholipase D1) by stimulating phosphoinositide synthesis via the STT4 PtdIns 4-kinase. Modulates ArfGAP function through effects on SPO14 activity. Inhibits phosphatidylcholine degradation by PLB1 (phospholipase B1). May also regulate post-Golgi membrane-trafficking events and have a role resistance to oxidative stress. {ECO:0000269|PubMed:10679005, ECO:0000269|PubMed:10848624, ECO:0000269|PubMed:12435498, ECO:0000269|PubMed:12824182, ECO:0000269|PubMed:12869188, ECO:0000269|PubMed:16126894, ECO:0000269|PubMed:16262726}.
MiscellaneousPresent with 9600 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the PITP family. {ECO:0000305}.
SimilarityContains 1 CRAL-TRIO domain. {ECO:0000255|PROSITE- ProRule:PRU00056}.
Subcellular LocationCytoplasm. Endosome.
SubunitForms a complex with 2 TSA2 subunits. Binds phosphatidylinositol (PtdIns).