LMPD Database

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LMP007121

UniProt Annotations

Entry Information
Gene NameUpc2p
Protein EntryUPC2_YEAST
UniProt IDQ12151
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionTranscription factor that is involved in activation of anaerobic genes such as DAN/TIR cell wall mannoprotein genes and YML083c. Appears to bind to anaerobic response elements (AR1) with the consensus sequence 5'-TCGTTYAG-3' present in the promoter regions of DAN/TIR genes. Involved in sterol uptake and regulation of the sterol biosynthesis. Binds to sterol regulatory elements (SRE) with the consensus sequence 5'-TCGTATA-3' present in ERG2 and ERG3 promoters. May be involved in down-regulation of CWP2 during anaerobic adaptation. {ECO:0000269|PubMed:11238402, ECO:0000269|PubMed:11292809, ECO:0000269|PubMed:11533229, ECO:0000269|PubMed:12077145, ECO:0000269|PubMed:12673627}.
InductionInduced by anaerobic conditions, hypoxia and cold. Repressed by heme
InductionInduced by anaerobic conditions, hypoxia and cold. Repressed by heme. {ECO:0000269|PubMed:11238402}.
MiscellaneousECM22 and UPC2 (in combination) null mutants are not viable.
MiscellaneousPresent with 752 molecules/cell in log phase SD medium
MiscellaneousPresent with 752 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityContains 1 Zn(2)-C6 fungal-type DNA-binding domain
SimilarityContains 1 Zn(2)-C6 fungal-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00227}.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00227, ECO:0000269|PubMed:14562095}.