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LMPD Database

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LMP007077

UniProt Annotations

Entry Information

Gene Name	sphinganine kinase LCB3
Protein Entry	DS1P1_YEAST
UniProt ID	P47013
Species	Yeast (S288c)

Comments

Comment type	Description
Function	Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases. Involved in endocytosis and calcium-mediated signaling. {ECO:0000269\|PubMed:10477278, ECO:0000269\|PubMed:10563329, ECO:0000269\|PubMed:10856228, ECO:0000269\|PubMed:11278643, ECO:0000269\|PubMed:11967828, ECO:0000269\|PubMed:12493772, ECO:0000269\|PubMed:12684378, ECO:0000269\|PubMed:12786943, ECO:0000269\|PubMed:9195906, ECO:0000269\|PubMed:9353337, ECO:0000269\|PubMed:9419344}.
Ptm	Glycosylated. {ECO:0000269\|PubMed:12786943}.
Similarity	Belongs to the type 2 lipid phosphate phosphatase family. {ECO:0000305}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269\|PubMed:10477278, ECO:0000269\|PubMed:10563329, ECO:0000269\|PubMed:9353337}; Multi-pass membrane protein {ECO:0000269\|PubMed:10477278, ECO:0000269\|PubMed:10563329, ECO:0000269\|PubMed:9353337}.