LMPD Database

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LMP007073

UniProt Annotations

Entry Information
Gene Nametype 1 serine/threonine-protein phosphatase catalytic subunit GLC7
Protein EntryPP12_YEAST
UniProt IDP32598
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 manganese ions per subunit. {ECO:0000250};
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Note=Binds 2 manganese ions per subunit. ;
FunctionComponent of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation.
FunctionInvolved in control of glycogen metabolism, meiosis, translation, chromosome segregation, cell polarity and G2/M cell cycle progression. PP1 may act in opposition to the IPL1 protein kinase in regulating chromosome segregation by dephosphorylating H3S10ph. The BUD14-GLC7 complex is necessary to regulate microtubule dynamics at the cortex and may function as a specific activator of the dynein complex.
InteractionP53858:BNI4; NbExp=4; IntAct=EBI-13715, EBI-3704; P27637:BUD14; NbExp=7; IntAct=EBI-13715, EBI-20747; P39732:GIP4; NbExp=4; IntAct=EBI-13715, EBI-20636; P41818:GLC8; NbExp=3; IntAct=EBI-13715, EBI-7629; P43638:MHP1; NbExp=3; IntAct=EBI-13715, EBI-10880; P42073:REF2; NbExp=7; IntAct=EBI-13715, EBI-14915; P34758:SCD5; NbExp=3; IntAct=EBI-13715, EBI-16685; P36047:SDS22; NbExp=6; IntAct=EBI-13715, EBI-16783; P50278:SOL1; NbExp=3; IntAct=EBI-13715, EBI-17675; P43587:YPI1; NbExp=4; IntAct=EBI-13715, EBI-22913;
MiscellaneousPresent with 14600 molecules/cell in log phase SD medium
MiscellaneousPresent with 14600 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the PPP phosphatase family. PP-1 subfamily
SimilarityBelongs to the PPP phosphatase family. PP-1 subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:12819204}. Nucleus {ECO:0000269|PubMed:12819204}.
Subcellular LocationCytoplasm . Nucleus .
SubunitProbably complexed with regulatory or targeting subunits. Interacts with BUD14. Component of the cleavage and polyadenylation factor (CPF) complex, which is composed of PTI1, SYC1, SSU72, GLC7, MPE1, REF2, PFS2, PTA1, YSH1/BRR5, SWD2, CFT2/YDH1, YTH1, CFT1/YHH1, FIP1 and PAP1. Component of the APT complex, which is a subcomplex of CPF, and is composed of PTI1, SYC1, SSU72, GLC7, REF2, PTA1 and SWD2. {ECO:0000269|PubMed:12477789, ECO:0000269|PubMed:12819204, ECO:0000269|PubMed:16107882}.