LMPD Database

LMP007037

UniProt Annotations

Entry Information
Gene Namephosphatidate phosphatase APP1
Protein EntryAPP1_YEAST
UniProt IDP53933
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityA 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate
Catalytic ActivityA 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate. {ECO:0000269|PubMed:23071111}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ;
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
DomainContains one Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif essential for phosphatidate phosphatase activity.
Enzyme RegulationInhibited by N-ethylmaleimide
Enzyme RegulationInhibited by N-ethylmaleimide. {ECO:0000269|PubMed:23071111}.
FunctionMg(2+)-dependent phosphatidate (PA) phosphatase which catalyzes the dephosphorylation of PA to yield diacylglycerol. May play a role in vesicular trafficking through its PAP activity at cortical actin patches
FunctionMg(2+)-dependent phosphatidate (PA) phosphatase which catalyzes the dephosphorylation of PA to yield diacylglycerol. May play a role in vesicular trafficking through its PAP activity at cortical actin patches. {ECO:0000269|PubMed:23071111}.
InteractionP15891:ABP1; NbExp=9; IntAct=EBI-28798, EBI-2036; P47068:BBC1; NbExp=3; IntAct=EBI-28798, EBI-3437; P38822:BZZ1; NbExp=14; IntAct=EBI-28798, EBI-3889; Q05080:HOF1; NbExp=2; IntAct=EBI-28798, EBI-5412; P53281:LSB1; NbExp=4; IntAct=EBI-28798, EBI-23329; P43603:LSB3; NbExp=8; IntAct=EBI-28798, EBI-22980; Q04439:MYO5; NbExp=2; IntAct=EBI-28798, EBI-11687; P80667:PEX13; NbExp=2; IntAct=EBI-28798, EBI-13206; Q06449:PIN3; NbExp=4; IntAct=EBI-28798, EBI-35523; P39743:RVS167; NbExp=9; IntAct=EBI-28798, EBI-14500; P32790:SLA1; NbExp=4; IntAct=EBI-28798, EBI-17313; P32793:YSC84; NbExp=6; IntAct=EBI-28798, EBI-24460;
MiscellaneousPresent with 2289 molecules/cell in log phase SD medium
MiscellaneousPresent with 2289 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PtmN-glycosylated
PtmN-glycosylated. {ECO:0000269|PubMed:19756047}.
Sequence CautionSequence=CAA59823.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Sequence CautionSequence=CAA59823.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Subcellular LocationCytoplasm, cytoskeleton, actin patch .
Subcellular LocationCytoplasm, cytoskeleton, actin patch {ECO:0000269|PubMed:11489916, ECO:0000269|PubMed:14562095}.
SubunitInteracts with ABP1
SubunitInteracts with ABP1. {ECO:0000269|PubMed:14737190}.