LMPD Database

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LMP006996

UniProt Annotations

Entry Information
Gene NamePpz1p
Protein EntryPPZ1_YEAST
UniProt IDP26570
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
CautionWas originally thought to originate from a rabbit cDNA library and was known as protein phosphatase Z (PP-Z)
CautionWas originally thought to originate from a rabbit cDNA library and was known as protein phosphatase Z (PP-Z). {ECO:0000305|PubMed:2166691}.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 manganese ions per subunit. {ECO:0000250};
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Note=Binds 2 manganese ions per subunit. ;
Enzyme RegulationInhibited by the regulatory subunits VHS3 and SIS2.
FunctionEssential for the maintenance of cell size and integrity in response to osmotic stress.
InteractionP36076:CAB3; NbExp=6; IntAct=EBI-13807, EBI-26778; P36024:SIS2; NbExp=5; IntAct=EBI-13807, EBI-17250; Q08438:VHS3; NbExp=4; IntAct=EBI-13807, EBI-30482;
MiscellaneousPresent with 217 molecules/cell in log phase SD medium
MiscellaneousPresent with 217 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the PPP phosphatase family. PP-Z subfamily
SimilarityBelongs to the PPP phosphatase family. PP-Z subfamily. {ECO:0000305}.
SubunitInteracts with SIS2 and VHS3, which regulate its activity. {ECO:0000269|PubMed:15192104, ECO:0000269|PubMed:9636153}.