LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP006994

UniProt Annotations

Entry Information
Gene Namephosphoacetylglucosamine mutase PCM1
Protein EntryAGM1_YEAST
UniProt IDP38628
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityN-acetyl-alpha-D-glucosamine 1-phosphate = N- acetyl-D-glucosamine 6-phosphate
Catalytic ActivityN-acetyl-alpha-D-glucosamine 1-phosphate = N- acetyl-D-glucosamine 6-phosphate. {ECO:0000269|PubMed:8174553}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:Q9P4V2}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250|UniProtKB:Q9P4V2};
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Note=Binds 1 Mg(2+) ion per subunit. ;
Disruption PhenotypeResults in undivided strings of cells and growth arrest after approximately 5 division cycles
Disruption PhenotypeResults in undivided strings of cells and growth arrest after approximately 5 division cycles. {ECO:0000269|PubMed:8174553}.
FunctionCatalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins (PubMed:8174553). Also has phosphoglucomutase activity (PubMed:8119301). {ECO:0000269|PubMed:8119301, ECO:0000269|PubMed:8174553}.
InteractionP40151:MGS1; NbExp=2; IntAct=EBI-2351, EBI-29152;
MiscellaneousPresent with 14700 molecules/cell in log phase SD medium
MiscellaneousPresent with 14700 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayNucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2
PathwayNucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2. {ECO:0000305|PubMed:8174553}.
SimilarityBelongs to the phosphohexose mutase family
SimilarityBelongs to the phosphohexose mutase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Subcellular LocationCytoplasm . Nucleus .