LMPD Database

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LMP006987

UniProt Annotations

Entry Information
Gene Nametype 2C protein phosphatase PTC5
Protein EntryPDP1_YEAST
UniProt IDQ12511
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity[Pyruvate dehydrogenase (acetyl-transferring)] phosphate + H(2)O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 magnesium or manganese ions per subunit. {ECO:0000250};
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Note=Binds 2 magnesium or manganese ions per subunit. ;
FunctionCatalyzes the dephosphorylation and concomitant reactivation of the E1 alpha subunit (PDA1) of the pyruvate dehydrogenase complex. {ECO:0000269|PubMed:16643908, ECO:0000269|PubMed:18180296}.
MiscellaneousPresent with 7550 molecules/cell in log phase SD medium
MiscellaneousPresent with 7550 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PtmProcessed by mitochondrial inner membrane protease (IMP) complex and released to the intermembrane space.
SimilarityBelongs to the PP2C family
SimilarityBelongs to the PP2C family. {ECO:0000305}.
SimilarityContains 1 PP2C-like domain
SimilarityContains 1 PP2C-like domain. {ECO:0000305}.
Subcellular LocationMitochondrion intermembrane space {ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:16643908, ECO:0000269|PubMed:22984289}.