LMPD Database

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LMP006936

UniProt Annotations

Entry Information
Gene Nameinositol phosphorylceramide synthase
Protein EntryAUR1_YEAST
UniProt IDP36107
SpeciesYeast (S288c)
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=555 uM for phosphatidylinositol {ECO:0000269|PubMed:19047657}; KM=3.0 uM for C(6)-NBD-ceramide {ECO:0000269|PubMed:19047657}; Vmax=824 pmol/min/mg enzyme for phosphatidylinositol {ECO:0000269|PubMed:19047657}; Vmax=367 pmol/min/mg enzyme for C(6)-NBD-ceramide {ECO:0000269|PubMed:19047657};
Biophysicochemical PropertiesKinetic parameters: KM=555 uM for phosphatidylinositol ; KM=3.0 uM for C(6)-NBD-ceramide ; Vmax=824 pmol/min/mg enzyme for phosphatidylinositol ; Vmax=367 pmol/min/mg enzyme for C(6)-NBD-ceramide ;
Enzyme RegulationInhibited by aureobasidin A (AbA), khafrefungin and rustmicin
Enzyme RegulationInhibited by aureobasidin A (AbA), khafrefungin and rustmicin. {ECO:0000269|PubMed:19047657}.
FunctionCatalytic component of the inositol phosphorylceramide synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis. {ECO:0000269|PubMed:19047657, ECO:0000269|PubMed:19726565, ECO:0000269|PubMed:9092515}.
InteractionQ06346:KEI1; NbExp=2; IntAct=EBI-2046036, EBI-38431;
MiscellaneousPresent with 4170 molecules/cell in log phase SD medium
MiscellaneousPresent with 4170 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the AUR1 family
SimilarityBelongs to the AUR1 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:10888667, ECO:0000269|PubMed:19726565}; Multi- pass membrane protein {ECO:0000269|PubMed:10888667, ECO:0000269|PubMed:19726565}.
Subcellular LocationGolgi apparatus, Golgi stack membrane ; Multi- pass membrane protein {ECO:0000269|PubMed:10888667, ECO:0000269|PubMed:19726565}.
SubunitComponent of the inositol phosphorylceramide synthase complex composed of at least AUR1 and KEI1.