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LMPD Database

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LMP006901

UniProt Annotations

Entry Information

Gene Name	Tsc11p
Protein Entry	TSC11_YEAST
UniProt ID	P40061
Species	Yeast (S288c)

Comments

Comment type	Description
Function	Essential component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway. TSC11 may exert its functions through two distinct mechanisms, one mediated by AVO1 and the other mediated by AVO2 and SLM1. {ECO:0000269\|PubMed:15809876}.
Interaction	P41318:LST8; NbExp=2; IntAct=EBI-22621, EBI-28598; P32600:TOR2; NbExp=5; IntAct=EBI-22621, EBI-19385;
Miscellaneous	Present with 1840 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Ptm	Phosphorylated by TOR2; when part of TORC2. {ECO:0000269\|PubMed:16002396, ECO:0000269\|PubMed:17330950, ECO:0000269\|PubMed:18407956, ECO:0000269\|PubMed:19779198}.
Similarity	Belongs to the pianissimo family. {ECO:0000305}.
Similarity	Contains 1 N-terminal Ras-GEF domain. {ECO:0000305}.
Subcellular Location	Cell membrane {ECO:0000269\|PubMed:12631735}; Peripheral membrane protein {ECO:0000269\|PubMed:12631735}; Cytoplasmic side {ECO:0000269\|PubMed:12631735}. Vacuole membrane {ECO:0000269\|PubMed:12631735}; Peripheral membrane protein {ECO:0000269\|PubMed:12631735}; Cytoplasmic side {ECO:0000269\|PubMed:12631735}.
Subunit	The target of rapamycin complex 2 (TORC2) is composed of at least AVO1, AVO2, BIT61, LST8, TOR2 and TSC11. TORC2 likely forms a homodimer. Contrary to TORC1, TORC2 does not bind to and is not sensitive to FKBP-rapamycin. TSC11 binds to the N-terminal HEAT repeat region in TOR2 and is required for TORC2 integrity by tethering AVO1 and AVO2 to the complex. {ECO:0000269\|PubMed:12408816, ECO:0000269\|PubMed:12631735, ECO:0000269\|PubMed:16002396}.