LMP006852 UniProt Annotations
Gene Name inositol polyphosphate kinase VIP1 Protein Entry VIP1_YEAST UniProt ID Q06685 Species Yeast (S288c)
Comment type Description Catalytic Activity ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate Catalytic Activity ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate. {ECO:0000269|PubMed:17412958}. Catalytic Activity ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate Catalytic Activity ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate. {ECO:0000269|PubMed:17412958}. Catalytic Activity ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate Catalytic Activity ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate. {ECO:0000269|PubMed:17412958}. Catalytic Activity ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate Catalytic Activity ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate. {ECO:0000269|PubMed:17412958}. Caution Although related to histidine acid phosphatase proteins, it lacks the conserved active sites, suggesting that it has no phosphatase activity Caution Although related to histidine acid phosphatase proteins, it lacks the conserved active sites, suggesting that it has no phosphatase activity. {ECO:0000305}. Function Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP- InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2- InsP4 (By similarity). Required for maintaining cellular integrity, normal growth and interactions with the ARP complex. Acts as a regulator of the PHO80-PHO85 cyclin/cyclin-dependent kinase (CDK) complex, thereby regulating signaling of phosphate availability. Required for the function of the cortical actin cytoskeleton, possibly by participating in correct F-actin localization and ensuring polarized growth. {ECO:0000250, ECO:0000269|PubMed:10388810, ECO:0000269|PubMed:17412958, ECO:0000269|PubMed:17412959}. Miscellaneous Present with 8810 molecules/cell in log phase SD medium Miscellaneous Present with 8810 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. Similarity Belongs to the histidine acid phosphatase family. VIP1 subfamily Similarity Belongs to the histidine acid phosphatase family. VIP1 subfamily. {ECO:0000305}. Subcellular Location Cytoplasm . Cytoplasm, cytoskeleton . Subcellular Location Cytoplasm {ECO:0000269|PubMed:14562095}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14562095}.
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