LMPD Database

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LMP006782

UniProt Annotations

Entry Information
Gene Namelipoprotein, Lp(a)
Protein EntryNONE_CAEEL
UniProt IDNONE
SpeciesHuman
Comments
Comment typeDescription
FunctionApo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. {ECO:0000269|PubMed:2531657}.
InteractionP02749:APOH; NbExp=4; IntAct=EBI-9232288, EBI-2114682; P02751:FN1; NbExp=2; IntAct=EBI-9232288, EBI-1220319;
MiscellaneousApo(a) is known to be proteolytically cleaved, leading to the formation of the so-called mini-Lp(a). Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis. O-glycosylation may limit the extent of proteolytic fragmentation. Homology with plasminogen kringles IV and V is thought to underlie the atherogenicity of the protein, because the fragments are competing with plasminogen for fibrin(ogen) binding.
PolymorphismThe reference genome sequence encodes a variant that contains 16 Kringle domains and that lack residues 533 to 3040. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 38 copies of the kringle-type repeats.
PtmN- and O-glycosylated. The N-glycans are complex biantennary structures present in either a mono- or disialylated state. The O- glycans are mostly (80%) represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated and non-sialylated O-glycans also detected.
SimilarityBelongs to the peptidase S1 family. Plasminogen subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
SimilarityContains 1 peptidase S1 domain. {ECO:0000255|PROSITE- ProRule:PRU00274}.
SimilarityContains 38 kringle domains. {ECO:0000255|PROSITE- ProRule:PRU00121}.
SubunitDisulfide-linked to apo-B100. Binds to fibronectin and decorin.
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APOA";