LMPD Database

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LMP006776

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol-4-phosphate 5-kinase-like 1
Protein EntryPI5L1_HUMAN
UniProt IDQ5T9C9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5T9C9-1; Sequence=Displayed; Name=2; IsoId=Q5T9C9-2; Sequence=VSP_024904; Note=No experimental confirmation available.;
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
CautionIt is unsure if the enzyme has intrinsic kinase activity.
FunctionMay act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.
SimilarityContains 1 PIPK domain. {ECO
Subcellular LocationCytoplasm. Membrane. Note=Localized to large cytoplasmic vesicular structures.
SubunitHeterodimerizes with other type I phosphatidylinositol 4- phosphate 5-kinase.