LMPD Database

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LMP006680

UniProt Annotations

Entry Information
Gene Namesteroid sulfatase (microsomal), isozyme S
Protein EntrySTS_HUMAN
UniProt IDP08842
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H(2)O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.
CofactorName=Ca(2+); Xref=ChEBI
DiseaseIchthyosis, X-linked (IXL) [MIM
FunctionConversion of sulfated steroid precursors to estrogens during pregnancy.
PtmThe conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
SimilarityBelongs to the sulfatase family.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein.
SubunitHomodimer.
Web ResourceName=Wikipedia; Note=Steroid sulfatase entry; URL="http://en.wikipedia.org/wiki/Steroid_sulfatase";