LMPD Database

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LMP006631

UniProt Annotations

Entry Information
Gene Namephospholipase A1 member A
Protein EntryPLA1A_HUMAN
UniProt IDQ53H76
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q53H76-1; Sequence=Displayed; Name=2; Synonyms=DeltaC; IsoId=Q53H76-2; Sequence=VSP_022508, VSP_022509; Name=3; IsoId=Q53H76-3; Sequence=VSP_022507; Note=No experimental confirmation available.; Name=4; IsoId=Q53H76-4; Sequence=VSP_044944; Note=No experimental confirmation available.;
FunctionHydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.
SimilarityBelongs to the AB hydrolase superfamily. Lipase family.
Subcellular LocationSecreted .
Tissue SpecificityWidely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney.