LMPD Database

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LMP006627

UniProt Annotations

Entry Information
Gene NameELOVL fatty acid elongase 7
Protein EntryA1L3X0_HUMAN
UniProt IDD6RHD0
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=2.6 uM for C18:3(n-3)-CoA ; KM=11.7 uM for malonyl-CoA ; Vmax=0.33 pmol/min/ug enzyme toward C18:3(n-3)-CoA ; Vmax=0.31 pmol/min/ug enzyme toward malonyl-CoA ;
Catalytic ActivityA very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
DomainThe di-lysine motif may confer endoplasmic reticulum localization.
FunctionCondensing enzyme that catalyzes the synthesis of saturated and polyunsaturated very long chain fatty acids. Highest activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. {ECO
Sequence CautionSequence=BAB15697.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAB15697.1; Type=Erroneous termination; Positions=52; Note=Translated as Gly.; Evidence= ; Sequence=BAB15697.1; Type=Frameshift; Positions=138; Evidence= ;
SimilarityBelongs to the ELO family.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue SpecificityExpressed in most tissues except heart and skeletal muscle.