LMPD Database

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LMP006618

UniProt Annotations

Entry Information
Gene NameTTK protein kinase
Protein EntryTTK_HUMAN
UniProt IDP33981
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P33981-1; Sequence=Displayed; Name=2; IsoId=P33981-2; Sequence=VSP_043072; Note=No experimental confirmation available.;
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
Enzyme RegulationInhibited by the ATP-competitive kinase inhibitor, SP600125.
FunctionPhosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.
Sequence CautionSequence=AAA61239.1; Type=Erroneous initiation; Evidence= ; Sequence=CAB87580.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the protein kinase superfamily. Ser/Thr protein kinase family.
SimilarityContains 1 protein kinase domain.
SubunitInteracts with TPR; the interactions occurs in a microtubule-independent manner. {ECO
Tissue SpecificityPresent in rapidly proliferating cell lines.