LMPD Database

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LMP006603

UniProt Annotations

Entry Information
Gene Nameacyl-CoA synthetase medium-chain family member 2
Protein EntryACSM2_MOUSE
UniProt IDQ8K0L3
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K0L3-1; Sequence=Displayed; Name=2; IsoId=Q8K0L3-2; Sequence=VSP_028393; Note=No experimental confirmation available.; Name=3; IsoId=Q8K0L3-3; Sequence=VSP_028394; Note=No experimental confirmation available.;
Catalytic ActivityATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Enzyme RegulationActivated by monovalent cations, such as potassium, rubidium or ammonium. {ECO:0000250}.
FunctionHas medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity). {ECO:0000250}.
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000250}.
SubunitMonomer. {ECO:0000250}.