LMPD Database

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LMP006600

UniProt Annotations

Entry Information
Gene Namephospholipase C, eta 2
Protein EntryPLCH2_MOUSE
UniProt IDQ6PAS6
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=A2AP18-1; Sequence=Displayed; Name=2; IsoId=A2AP18-2; Sequence=VSP_029082, VSP_029083; Name=3; IsoId=A2AP18-3; Sequence=VSP_029081, VSP_029084; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay..; Name=4; IsoId=A2AP18-4; Sequence=VSP_029075, VSP_029077; Name=5; IsoId=A2AP18-5; Sequence=VSP_029076, VSP_029078, VSP_029079;
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108;
Developmental StageExpressed at 2 weeks after birth but barely detected 1 week after birth. Increased expression during brain development. {ECO:0000269|PubMed:15899900}.
FunctionThe production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain. {ECO:0000269|PubMed:15899900, ECO:0000269|PubMed:16107206}.
Sequence CautionSequence=BAC32005.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC32005.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAC37371.1; Type=Erroneous termination; Positions=433; Note=Translated as Tyr.; Evidence={ECO:0000305}; Sequence=CAO78007.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAO78129.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
SimilarityContains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
SimilarityContains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:15899900}. Cell membrane {ECO:0000269|PubMed:15899900}. Note=Localized predominantly at the plasma membrane.
Tissue SpecificitySpecifically detected in the brain, with higher level in cerebral cortex, olfactory bulb and hippocampus (at protein level). Expressed in the pyramidal cells of the hippocampus, but also in eye and lung. {ECO:0000269|PubMed:15899900, ECO:0000269|PubMed:16107206}.