LMPD Database

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LMP006598

UniProt Annotations

Entry Information
Gene Namepatatin-like phospholipase domain containing 7
Protein EntryPLPL7_MOUSE
UniProt IDA2AJ88
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2AJ88-1; Sequence=Displayed; Name=2; Synonyms=mNREV1; IsoId=A2AJ88-2; Sequence=VSP_026506, VSP_026507; Name=3; Synonyms=mNREV2; IsoId=A2AJ88-3; Sequence=VSP_053967, VSP_053968;
CautionIt is uncertain whether Met-1 or Met-27 is the initiator. {ECO:0000305}.
FunctionSerine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy (By similarity). Isoform 1 and isoform 2 have equal enzyme activity. Isoform 3 has no enzyme activity. {ECO:0000250, ECO:0000269|PubMed:22326266}.
InductionBy nutritional conditions. Expression of isoform 3 is switched to the expression of isoform 2 during fasting. In the examined tissues, high expression levels of isoform 3 are detected in fed status, but expression is significantly decreased to about one fourth in fasted status. Isoform 2 expression levels are down- regulated under fed status and are up-regulated in fasted status. Isoform 1 expression levels are not affected by fasting. {ECO:0000269|PubMed:22326266}.
Sequence CautionSequence=AAH27342.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH27342.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAI41366.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI41367.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC40302.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAE28519.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAE41783.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the NTE family. {ECO:0000305}.
SimilarityContains 1 patatin domain. {ECO:0000305}.
SimilarityContains 3 cyclic nucleotide-binding domains. {ECO:0000255|PROSITE-ProRule:PRU00060}.
Subcellular LocationIsoform 1: Endoplasmic reticulum membrane; Single-pass membrane protein.
Subcellular LocationIsoform 2: Endoplasmic reticulum membrane; Single-pass membrane protein.
Subcellular LocationIsoform 3: Endoplasmic reticulum membrane; Single-pass membrane protein.
Subcellular LocationMembrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Found in the nuclear, mitochondrial, lysosomal, and microsomal fractions. {ECO:0000250}.
Tissue SpecificityIsoform 1, isoform 2 and isoform 3 are expressed in white adipose tissue, cardiac muscle, skeletal muscle, and testis. {ECO:0000269|PubMed:22326266}.