LMPD Database

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LMP006596

UniProt Annotations

Entry Information
Gene Namepatatin-like phospholipase domain containing 8
Protein EntryPLPL8_MOUSE
UniProt IDQ8K1N1
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
Enzyme RegulationInhibited by E-6-bromomethylene-3-1- naphthalenyl-2H-tetrahydropyran-2-one (BEL). {ECO:0000250}.
FunctionCalcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAH19364.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB23417.1; Type=Erroneous termination; Positions=777; Note=Translated as stop.; Evidence={ECO:0000305};
SimilarityContains 1 patatin domain. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.