LMPD Database

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LMP006595

UniProt Annotations

Entry Information
Gene Namepatatin-like phospholipase domain containing 6
Protein EntryPLPL6_MOUSE
UniProt IDQ3TRM4
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3TRM4-1; Sequence=Displayed; Name=2; IsoId=Q3TRM4-2; Sequence=VSP_026390; Note=No experimental confirmation available.; Name=3; IsoId=Q3TRM4-3; Sequence=VSP_026390, VSP_026391; Note=No experimental confirmation available.; Name=4; IsoId=Q3TRM4-4; Sequence=VSP_026392, VSP_026393; Note=No experimental confirmation available.;
Catalytic Activity2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
Developmental StageExpressed in the embryonic respiratory system, different epithelial structures and strongly in the spinal ganglia, during the development. {ECO:0000269|PubMed:10640712}.
Enzyme RegulationInhibited by a series a OPs such as mipafox (MPX), phenyl saligenin phosphate (PSP), phenyl dipentyl phosphinate (PDPP), diisopropyl fluorophosphate and paraoxon. {ECO:0000269|PubMed:16963094}.
FunctionPhospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. {ECO:0000269|PubMed:12640454, ECO:0000269|PubMed:16963094}.
PtmGlycosylated. {ECO:0000250}.
SimilarityBelongs to the NTE family. {ECO:0000305}.
SimilarityContains 1 patatin domain. {ECO:0000305}.
SimilarityContains 3 cyclic nucleotide-binding domains. {ECO:0000255|PROSITE-ProRule:PRU00060}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:16963094}; Single-pass type I membrane protein {ECO:0000269|PubMed:16963094}; Cytoplasmic side {ECO:0000269|PubMed:16963094}. Note=Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment.
Tissue SpecificityExpressed ubiquitously in brain of young mice. Reaching adulthood, there is a most prominent expression in Purkinje cells, granule cells and pyramidal neurons of the hippocampus and some large neurons in the medulla oblongata, nucleus dentatus and pons. {ECO:0000269|PubMed:10640712}.