LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP006593

UniProt Annotations

Entry Information
Gene Namephospholipase C, beta 2
Protein EntryPLCB2_MOUSE
UniProt IDQ3V3V2
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=A3KGF7-1; Sequence=Displayed; Name=2; IsoId=A3KGF7-2; Sequence=VSP_026982, VSP_026985, VSP_026986; Name=3; IsoId=A3KGF7-3; Sequence=VSP_026985, VSP_026986; Name=4; IsoId=A3KGF7-4; Sequence=VSP_026981, VSP_026983, VSP_026984;
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
FunctionThe production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This protein may be involved in the transduction of bitter taste stimuli (By similarity). {ECO:0000250}.
MiscellaneousThe receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha- 16. {ECO:0000250}.
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
SimilarityContains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
SimilarityContains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
SubunitInteracts with RAC1. {ECO:0000250}.