LMPD Database

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LMP006589

UniProt Annotations

Entry Information
Gene Namehydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit
Protein EntryECHA_MOUSE
UniProt IDQ8BMS1
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl- CoA + H(2)O.
Catalytic ActivityA long-chain (S)-3-hydroxyacyl-CoA + NAD(+) = a long-chain 3-oxoacyl-CoA + NADH.
FunctionBifunctional subunit.
PathwayLipid metabolism; fatty acid beta-oxidation.
PtmAcetylation of Lys-569 and Lys-728 is observed in liver mitochondria from fasted mice but not from fed mice. {ECO:0000269|PubMed:16916647, ECO:0000269|PubMed:23576753, ECO:0000269|PubMed:23806337}.
SimilarityIn the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family. {ECO:0000305}.
SimilarityIn the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000250}.
SubunitOctamer of 4 alpha (HADHA) and 4 beta (HADHB) subunits. {ECO:0000250}.