LMPD Database

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LMP006583

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol 4-kinase type 2 beta
Protein EntryP4K2B_MOUSE
UniProt IDQ8CBQ5
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CBQ5-1; Sequence=Displayed; Name=2; IsoId=Q8CBQ5-2; Sequence=VSP_024828;
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Enzyme RegulationRecruited and activated by membrane association. Binding to the microsomal membrane has been shown to enhance its activity (By similarity). {ECO:0000250}.
FunctionTogether with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking (By similarity). {ECO:0000250}.
SimilarityBelongs to the PI3/PI4-kinase family. Type II PI4K subfamily. {ECO:0000305}.
SimilarityContains 1 PI3K/PI4K domain. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac-GTP-dependent mechanism (By similarity). {ECO:0000250}.