LMPD Database

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LMP006580

UniProt Annotations

Entry Information
Gene Nameacetyl-Coenzyme A carboxylase alpha
Protein EntryQ5SWU9_MOUSE
UniProt IDQ5SWU9
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative promoter usage; Named isoforms=2; Name=1; IsoId=Q5SWU9-1; Sequence=Displayed; Name=2; IsoId=Q5SWU9-2; Sequence=VSP_026101;
Catalytic ActivityATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA. {ECO:0000250|UniProtKB:P11497, ECO:0000269|PubMed:20952656}.
Catalytic ActivityATP + biotin-[carboxyl-carrier-protein] + CO(2) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier- protein].
CofactorName=biotin; Xref=ChEBI:CHEBI:57586; Evidence= ; Note=Biotin. ;
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Note=Binds 2 manganese ions per subunit. ;
Enzyme RegulationBy phosphorylation (By similarity). Activity is increased by oligomerization. Citrate and MID1IP1 promote oligomerization.
FunctionCatalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (By similarity).
PathwayLipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
PtmPhosphorylation on Ser-1262 is required for interaction with BRCA1.
SimilarityContains 1 ATP-grasp domain. {ECO:0000255|PROSITE- ProRule:PRU00409}.
SimilarityContains 1 biotin carboxylation domain.
SimilarityContains 1 biotinyl-binding domain.
SimilarityContains 1 carboxyltransferase domain.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:12360400, ECO:0000269|PubMed:20952656}.
SubunitMonomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity. {ECO:0000269|PubMed:12360400, ECO:0000269|PubMed:20952656}.