LMPD Database

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LMP006571

UniProt Annotations

Entry Information
Gene Namephospholipase A1 member A
Protein EntryPLA1A_MOUSE
UniProt IDQ8VI78
SpeciesMouse
Comments
Comment typeDescription
FunctionHydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production (By similarity). {ECO:0000250}.
SimilarityBelongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}.
Subcellular LocationSecreted {ECO:0000305}.