LMPD Database

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LMP006565

UniProt Annotations

Entry Information
Gene Name24-dehydrocholesterol reductase
Protein EntryDHC24_MOUSE
UniProt IDQ8VCH6
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity5-alpha-cholest-7-en-3-beta-ol + NADP(+) = 5- alpha-cholesta-7,24-dien-3-beta-ol + NADPH.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
FunctionCatalyzes the reduction of the delta-24 double bond of sterol intermediates. {ECO:0000250}.
PathwaySteroid biosynthesis; cholesterol biosynthesis.
Sequence CautionSequence=BAC97846.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the FAD-binding oxidoreductase/transferase type 4 family. {ECO:0000305}.
SimilarityContains 1 FAD-binding PCMH-type domain. {ECO:0000255|PROSITE-ProRule:PRU00718}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.