LMPD Database

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LMP006564

UniProt Annotations

Entry Information
Gene Namelow density lipoprotein receptor class A domain containing 3
Protein EntryLRAD3_MOUSE
UniProt IDB7ZND2
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2AR95-1; Sequence=Displayed; Name=2; IsoId=A2AR95-2; Sequence=VSP_027620; Name=3; IsoId=A2AR95-3; Sequence=VSP_027619;
FunctionMay influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. {ECO:0000269|PubMed:21795536}.
Sequence CautionSequence=BAC27759.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the LDLR family. {ECO:0000305}.
SimilarityContains 3 LDL-receptor class A domains. {ECO:0000255|PROSITE-ProRule:PRU00124}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:21795536}; Single-pass type I membrane protein {ECO:0000269|PubMed:21795536}.
SubunitInteracts with APP precursor C-terminus. {ECO:0000269|PubMed:21795536}.
Tissue SpecificityExpressed in the cerebral cortex and hippocampus. {ECO:0000269|PubMed:21795536}.