LMPD Database

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LMP006561

UniProt Annotations

Entry Information
Gene Namefatty acid desaturase 1
Protein EntryFADS1_MOUSE
UniProt IDQ920L1
SpeciesMouse
Comments
Comment typeDescription
DomainThe histidine box domains may contain the active site and/or be involved in metal ion binding.
FunctionComponent of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3) respectively (By similarity). {ECO:0000250}.
InductionExpression in liver is down-regulated by dietary PUFA. {ECO:0000269|PubMed:11792729}.
PathwayLipid metabolism; polyunsaturated fatty acid biosynthesis.
SimilarityBelongs to the fatty acid desaturase family. {ECO:0000305}.
SimilarityContains 1 cytochrome b5 heme-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00279}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Mitochondrion {ECO:0000250}.
Tissue SpecificityHighly expressed in the adrenal gland, liver, brain, and testis, tissues where lipogenesis and steroidogenesis are active. {ECO:0000269|PubMed:11792729}.