LMPD Database

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LMP006555

UniProt Annotations

Entry Information
Gene Namemyotubularin related protein 12
Protein EntryMTMRC_MOUSE
UniProt IDQ80TA6
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80TA6-1; Sequence=Displayed; Name=2; IsoId=Q80TA6-2; Sequence=VSP_030723;
CautionLacks the phosphocysteine intermediate Cys active site in position 391 that is replaced by a Glu residue, preventing the hydrolase activity. {ECO:0000305}.
FunctionCatalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location. {ECO:0000250}.
Sequence CautionSequence=BAC36227.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC65821.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. {ECO:0000305}.
SimilarityContains 1 myotubularin phosphatase domain. {ECO:0000255|PROSITE-ProRule:PRU00669}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitInteracts with myotubularin MTM1 and myotubularin-related MTMR2. {ECO:0000250}.