LMPD Database

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LMP006533

UniProt Annotations

Entry Information
Gene Namexylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
Protein EntryB4GT7_HUMAN
UniProt IDQ9UBV7
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityUDP-alpha-D-galactose + O-beta-D-xylosyl- [protein] = UDP + 4-beta-D-galactosyl-O-beta-D-xylosyl-[protein].
CofactorName=Mn(2+); Xref=ChEBI
DiseaseEhlers-Danlos syndrome, progeroid type, 1 (EDSP1) [MIM
FunctionRequired for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 7 family.
Subcellular LocationGolgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Cis cisternae of Golgi stack.
Tissue SpecificityHigh expression in heart, pancreas and liver, medium in placenta and kidney, low in brain, skeletal muscle and lung.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=Beta-1,4-galactosyltransferase 7; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_442";
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B4GALT7";