LMPD Database

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LMP006517

Record overview

LMPD IDLMP006517
Gene ID8574
SpeciesHomo sapiens (Human)
Gene Namealdo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
Gene SymbolAKR7A2
SynonymsAFAR; AFAR1; AFB1-AR1; AKR7
Alternate namesaflatoxin B1 aldehyde reductase member 2; AFB1-AR 1; HEL-S-166mP; SSA reductase; aldoketoreductase 7; AFB1 aldehyde reductase 1; succinic semialdehyde reductase; aflatoxin beta1 aldehyde reductase; epididymis secretory sperm binding protein Li 166mP
Chromosome1
Map Location1p36.13
EC Number1.1.1.n11
SummaryThe protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. [provided by RefSeq, Oct 2011]
OrthologsView orthologs and multiple alignments for AKR7A2

Proteins

aflatoxin B1 aldehyde reductase member 2
Refseq ID:NP_003680
Protein GI:41327764
UniProt ID:O43488
mRNA ID:NM_003689
Length:359
RefSeq Status:REVIEWED
MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRV
KIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMY
NATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMY
HHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR